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Both animal and epidemiologic studies indicate that the ratio of n-3 to n-6 fatty acids in the diet is particularly important to the reduction of cancer risk. In animal studies the ratio of 1.2:1 has reduced cancer incidence (68 ). n-3 consumption was not significantly correlated to cancer incidence, but the ratio of n-3 to n-6 fatty acids in the diet was significantly inversely correlated to breast cancer incidence in three of four European countries examined in one study (69 ) and in France (70 ). In the French study, the odds ratio for breast cancer in the quartile with the highest ratio of n-3 to n-6 fatty acids consumed was 0.3 compared with an odds ratio of 1 for the quartile with the lowest the ratio of n-3 to n-6 fatty acids (70 ). Because these are epidemiologic studies there is no way to tell whether the reduced risk for cancer was due to reduced cell transformation or to death of the transformed cells before an overt cancer developed.